Lys-Glu modified curcumin and preparation thereof, as well as biological activity and application

• Main Authors: ZHAO LICHUN, HU XI, ZHAO MING, PENG SHIQI
• Format: Patent
• Language: Chinese; English
• Published: 25.01.2017
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses Lys-Glu modified curcumin, and discloses a preparation method of the Lys-Glu modified curcumin, activity of the Lys-Glu modified curcumin in resisting tumor cell proliferation, an effect of the Lys-Glu modified curcumin of inhibiting migration and invasion of A549 cells, activity of the Lys-Glu modified curcumin in inhibiting weight gain of the tumor of a tumor-bearing mice S180, activity of the Lys-Glu modified curcumin in inhibiting transferring of Lewis lung cancer, activity of the Lys-Glu modified curcumin in inhibiting ear swelling, induced by xylene, of the mice, and activity of the Lys-Glu modified curcumin in inhibiting generation of thrombus of a wistar. 本发明公开了Lys-Glu修饰的姜黄素，公开了它的制备方法，公开了它抗肿瘤细胞增殖的活性，公开了它抑制A549细胞的迁移和侵袭的作用，公开了它抑制S180荷瘤小鼠瘤体增重的活性，公开了它抑制Lewis肺癌转移的活性，进步公开了它抑制二甲苯诱导小鼠耳肿胀的活性，进步公开了它抑制大鼠血栓生成活性。