YIGSR修饰的姜黄素,其制备,生物活性和应用

• Format: Patent
• Language: Chinese
• Published: 26.07.2019
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

本发明公开了下式的姜黄素与寡肽Tyr-Ile-Gly-Ser-Arg的偶联物，公开了它的制备方法，公开了它抗肿瘤细胞增殖的活性，公开了它抑制A549细胞的迁移和侵袭的作用，公开了它抑制S180荷瘤小鼠瘤体增重的活性，公开了它抑制Lewis肺癌转移的活性，进一步公开了它抑制二甲苯诱导小鼠耳肿胀的活性，进一步公开了它抑制大鼠血栓生成活性。 The invention discloses a curcumin and oligopeptide Tyr-Ile-Gly-Ser-Arg conjugate of the following formula, a preparation method thereof, its activity of inhibiting tumor cell proliferation, its effect of inhibiting migration and invasion of A549 cells, its activity of inhibiting S180 tumor-bearing mice tumor weight increase, its activity of inhibiting Lewis lung cancer metastasis, its activity of inhibiting xylene induced mice ear swelling, and further discloses its activity of inhibiting rat thrombosis.