Targeting molecule and utilization thereof

• Main Authors: NIITSU YOSHIRO, MINOMI KENJIRO, TAKAHASHI HIROKAZU, TERADA ERIKA
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided are: a targeting molecule targeting a target cell which is selected from the group consisting of a stellate cell, a myofibroblast, a cancer-associated fibroblast, a tumor cell and a cell expressing STRA6, said targeting molecule being selected from the group consisting of (1) a peptide containing an amino acid sequence in the cell-binding region of RBP, (2) a variant peptide of the aforesaid peptide (1), said variant peptide having a comparable targeting ability to peptide (1), and (3) a peptide mimetic having a comparable targeting ability to peptide (1) or peptide (2); a targeting agent, a carrier, a complex and a medicinal composition each comprising the targeting molecule; a method for treating, examining, diagnosing or monitoring a disease related to the aforesaid target cell; a method for labeling, detecting or imaging the target cell, etc. 本发明涉及以选自由星状细胞、肌成纤维细胞、癌相关成纤维细胞、肿瘤细胞及STRA6表达细胞组成的组中的靶细胞为靶的靶向分子，含有该靶向分子的靶向剂、载体、复合物及医药组合物，对与所述靶细胞相关的疾病进行处置、检査、诊断或监测的方法及对所述靶细胞进行标记、监测或成像的方法等，所述靶向分子选自由下述(1)～(3)组成