Y-type multiethylene glycol derivative and preparation method thereof

• Main Authors: ZHU HUI, CHEN XIAOMENG, ZHAO XUAN, LIN MEINA, ZHU ZHENGANG
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a Y-type multiethylene glycol derivative and a preparation method thereof. The Y-type multiethylene glycol derivative has the advantages of determined molecular weight and chain segment number and can avoid the nonuniformity defect of a PEG derivative; meanwhile, the preparation method is simple in step and mild in condition, a strict waterless environment is not needed, and the protection and deprotecion steps are not needed. In addition, Y-type multiethylene glycol has the advantages that the water solubility of multiethylene glycol is improved, and the problem that when multiethylene glycol is used for modifying an insoluble drug, insufficient water solubility is caused by improvement of the loading capacity can be solved. 本发明公开了种Y型多缩乙二醇衍生物及其制备方法，具有分子量和链段数确定的优点，能够避免PEG衍生物本身不均的不足，同时制备方法步骤简单，条件温和，不需要严格的无水环境，也不需要进行保护和脱保护的步骤。另外，本发明所述的Y型多缩乙二醇增加了多缩乙二醇的水溶性，能够解决多缩乙二醇修饰不溶性药物时，由于负载量的提高造成水溶性不足的问题。