Pharmaceutical composition with palmitoyl ascorbate and antitumor medicine in synergism

• Main Authors: YANG YUE, ZHANG LING, CHEN XIJING, MA ENLONG, LU YANG, CHEN QI, ZHAO DI, LI NING, WANG ZIHOU
• Format: Patent
• Language: Chinese; English
• Published: 23.11.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a medicine for treating malignant tumors, in particular to an L-palmitoyl ascorbate antitumor medicine applied in the way of intravenous injection or oral administration or intratumor injection or the like. The pharmaceutically acceptable medicine applied in an injection or oral administration dosage form is prepared from L-palmitoyl ascorbate or/and one or more kinds of other chemotherapeutic medicine in combination. The medicine has high physicochemical stability and a definite antitumor effect; in-vitro cell tests and tumor-bearing mouse tests show that the medicine or a composition thereof has an effect on various malignant tumors such as breast cancer, liver cancer, lung cancer, stomach cancer, pancreatic cancer, cervical cancer, gliomas, prostatic cancer and colorectal cancer. 本发明涉及种治疗恶性肿瘤的药物，尤其是用于静脉注射和口服或瘤内注射等途径给药的维生素C棕榈酰酯抗癌药物，它以维生素C棕榈酰酯或和种或多种其它化疗药物合用，制备成药学上可接受的注射或口服剂型给药。本发明的药物，有优良的物理化学稳定性和确切的抗肿瘤作用，体外细胞试验及荷瘤小鼠试验表明，本药物或其组合物对乳腺癌、肝癌、肺癌、胃癌、胰腺癌、宫颈癌、胶质瘤、前列腺癌、结直肠癌等多种恶性肿瘤有效。