MGLU2/3 antagonists for the treatment of intellectual disabilities

• Main Authors: GATTI MCARTHUR SILVIA, BALLARD THERESA M, SAXE MICHAEL, WICHMANN JUERGEN, WOLTERING THOMAS
• Format: Patent
• Language: Chinese; English
• Published: 16.11.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses MGLU2/3 antagonists for the treatment of intellectual disabilities. This invention relates to a new medical use for certain chemical compounds and pharmaceutical compositions containing them. The invention relates to compounds which are mGlu2/3 negative allosteric modulators for use in the treatment of intellectual disabilities. In another aspect, the invention relates to a pharmaceutical composition for use in the treatment of intellectual disabilities comprising a compound according to the invention and a pharmaceutically acceptable carrier. 本发明涉及些化学化合物的新的医药用途以及含有所述化合物的药物组合物。本发明涉及作为mGlu2/3负变构调节剂用于治疗智力残疾的化合物。在另个方面，本发明涉及包含根据本发明的化合物和药用载体的用于治疗智力残疾的药物组合物。