Synthetic method of carbenicillin sulphate impurity-D

• Main Authors: CUI WANSHENG, GUAN HAIYING, JIANG HAIPING, SHANG DING, ZENG CHUIYU
• Format: Patent
• Language: Chinese; English
• Published: 16.11.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention provides a synthetic method of carbenicillin sulphate impurity-D. The synthetic method is characterized in that carbenicillin sulphate is subjected to degradation reaction under the action of strong base at the temperature below 50 DEG C to obtain the carbenicillin sulphate impurity-D; degradation reaction is conducted in deuterated solvent. According to the carbenicillin sulphate impurity-D prepared with the method, mutual conversion between the arbenicillin sulphate impurity-D and rbenicillin sulphate impurity-G can be effectively controlled, the carbenicillin sulphate impurity-D is environment friendly, simpler and safer to prepare and high in purity, and a guarantee is provided to quality detection and research of impurities of carbenicillin sulphate products. 本发明提供了种羧苄西林钠杂质D的合成方法，其特征在于：在低于50℃的温度下，羧苄西林钠在强碱的作用下，通过降解反应获得羧苄西林钠杂质D；其中，所述降解反应在氘代溶剂中进行。利用本发明方法进行制备的羧苄西林钠杂质D，可以有效控制羧苄西林钠杂质D和羧苄西林钠杂质G的互相转化，环境友好，制备更简便安全，产品纯度高，为羧苄西林钠产品的杂质质量检控研究提供保障。