Means and methods for assessing hematopoietic toxicity

• Main Authors: FABIAN ERIC, LOOSER RALF, STRAUSS VOLKER, RAVENZWAAY BENNARD VAN, MELLERT WERNER, PROKOUDINE ALEXANDRE, WALK TILMANN B, WIEMER JAN C, HEROLD MICHAEL MANFRED, KAMP HENNICKE
• Format: Patent
• Language: Chinese; English
• Published: 26.10.2016
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

A method for diagnosing hematopoietic toxicity comprises: a) determining the amount of at least one biomarker in a test sample of a subject suspected to suffer from hematopoietic toxicity, and b) comparing the amounts determined in step a) to a reference, whereby hematopoietic toxicity is to be diagnosed. A method for determining whether a compound is capable of inducing such hematopoietic toxicity in a subject, a method of identifying a drug for treating hematopoietic toxicity, a device and a kit for diagnosing hematopoietic toxicity are also disclosed. 诊断造血毒性的方法，所述方法包括：(a)在疑为罹患造血毒性的对象的测试样品中测定至少种生物标记物的量，和(b)比较在步骤(a)中测定的量和参考，由此诊断造血毒性。也公开了测定化合物是否能够在对象中诱导这样的造血毒性的方法，鉴定用于治疗造血毒性的药物的方法，用于诊断造血毒性的设备和试剂盒。