17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl derivatives, methods for the production thereof and the use thereof for treating diseases

• Main Authors: ROTGERI ANDREA, BONE WILHELM, KLAR ULRICH, SCHWEDE WOLFGANG, MOLLER CARSTEN
• Format: Patent
• Language: Chinese; English
• Published: 26.10.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene 11-aryl derivatives of the formula I with progesterone-antagonising action and to processes for preparation thereof, to use thereof for treatment and/or prophylaxis of disorders and to the use thereof for production of medicaments for treatment and/or prophylaxis of disorders, especially of fibroids of the uterus (myomas, uterine leiomyomas), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers and complaints associated with the menopause, or for fertility control and emergency contraception. 本发明涉及表现出孕酮拮抗作用的式(I)的17-羟基-17-五氟乙基-雌-4,9(10)-二烯-11-芳基衍生物及其制备方法、其用于治疗和/或预防疾病的用途，以及其用于制备用以治疗和/或预防疾病或用以节育和紧急事后避孕的药品的用途，所述疾病特别是子宫纤维瘤(肌瘤，子宫平滑肌瘤)、子宫内膜异位症、月经过多、脑膜瘤、激素依赖性乳腺癌以及与绝经相关的疾病。