Nicotinamide production method

• Main Authors: LONG LAIZAO, SU ZHANJUN, MA FUBEI, LIU YAMING, ZOU JINXIN
• Format: Patent
• Language: Chinese; English
• Published: 26.10.2016
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention relates to the technical field of fine chemical engineering, in particular to a nicotinamide production method. The method comprises the steps that in the hydrolytic process, water is adopted as a solvent, manganese dioxide is adopted as a catalyst, 3-cyanopyridine is subjected to heating and hydrolysis reaction, in the hydrolysis reaction process, alcohol is not needed to serve as a solvent, the production cost of nicotinamide is reduced, the yield of nicotinamide is high and can reach 85% or above, the purity of the product is determined through a high performance liquid chromatography method, the purity can reach 99.93% or above, the cost of recycling the solvent and the catalyst manganese dioxide is effectively reduced, the waste rate of the raw materials is decreased, and the emission rate of liquid waste is decreased. 本发明涉及精细化工技术领域，尤其是种烟酰胺生产方法，通过在水解过程中，采用水作为溶剂、二氧化锰作为催化剂，将3-氰基吡啶进行加热水解反应，使得在水解反应过程中，无需采用醇作为溶剂，降低了烟酰胺的生产成本，而且使得烟酰胺的产率较高，能够达到85％以上，产品的纯度采用高效液相色谱法测定，其能够达到99.93％以上，有效的降低了对溶剂和催化剂二氧化锰回