Preparation method for 5-(4-chlorobenzyl)-2,2-dimethylcyclopentanone

• Main Authors: ZHOU QIN, LI FANG, LI HAITAO, ZHANG ZHUANHAO, ZHAN JIARONG
• Format: Patent
• Language: Chinese; English
• Published: 26.10.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method for 5-(4-chlorobenzyl)-2,2-dimethylcyclopentanone. According to the method, p-chlorobenzaldehyde and 2,2-dimethyl-4-cyclopenten-1-ketone, namely, the compound in formula I serve as initial raw materials, by means of aldol condensation, hydrogenation, hydroxyl removal and further hydrogenation, and a compound, namely an intermediate 5-(4-chlorobenzyl)-2,2-dimethylcyclopentanone of metconazole, in formula V is obtained. Compared with the prior art, high-danger compound sodium hydride is avoided, high-toxicity methylation and other operation are avoided, reaction is mild and easy to control, the purity of the target product 5-(4-chlorobenzyl)-2,2-dimethylcyclopentanone is higher than 95%, the total yield can reach 65% or above, and the preparation method meets the requirements of green chemical industries and is suitable for industrial production. 本发明公开了种2,2-二甲基-5-(4-氯苄基)环戊酮的制备方法，该方法以对氯苯甲醛和2,2-二甲基-4-环戊烯-1-酮即式I化合物为初始原料，经过羟醛缩合、氢化、羟基脱除以及进步氢化反应，制得式V化合物，即叶菌唑的中间体2,2-二甲基-5-(