Method for measuring concentration of flutrimazole in plasma

• Main Authors: ZHANG NONGSHAN, LI CHANGYIN, JU WENZHENG, ZHANG JUN, XU MEIJUAN, DAI GUOLIANG, FENG LIWEN, WU TING, CHU JIHONG, LIU SHIJIA
• Format: Patent
• Language: Chinese; English
• Published: 12.10.2016
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method for measuring concentration of flutrimazole in plasma. A liquid chromatography-mass spectrometry system is used for carrying out measuring, a sample to be measured is firstly taken, a certain amount of an organic solvent liquid-liquid extraction agent is added for liquid-liquid extraction, after pretreatment, chromatographic column separation is carried out, and a mass spectrometry detector is used for carrying out detection. According to the method, quickness and accuracy are achieved, sensitivity is high, and operation is easy and convenient; the method is suitable for measuring the concentration of the flutrimazole in the plasma. 本发明公开了种测定血浆中氟曲马唑浓度的方法，采用液质联用系统测定，先取待测样品，加入定量的有机溶媒液液萃取剂进行液液萃取，预处理后，经色谱柱分离，用质谱检测器检测，本发明方法快速、准确、灵敏度高、操作简便，适合于测定血浆中氟曲马唑的浓度。