BORON-CONTAINING SMALL MOLECULES

• Main Authors: ZHANG YOUG-KANG, STEMPHOSKI AARON M, AKAMA TSUTOMU, ROCK FERNANDO, HERNANDEZ VINCENT, MAO WEIMIN, SANDERS VIRGINIA, MAPLES KIRK R, ZEGAR SIEAD, BAKER STEPHEN J, PLATNER JACOB J, KENNEDY ISAAC, LIKHOTVORIK IGOR, YIANNIKOUROS GEORGE PETROS, ZHOU HUCHEN, ALLEY MICHAEL RICHARD KEVIN, DIPIERRO MICHAEL, BENKOVIC STEPHEN J, HOLD KARIN M
• Format: Patent
• Language: Chinese; English
• Published: 12.10.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate. 本发明涉及含硼的小分子，具体涉及用于治疗真菌感染，更具体地说为局部治疗甲癣和/或皮肤真菌感染的化合物。本发明涉及对真菌具有活性并且在接触患者时能够使化合物到达受真菌感染的皮肤、指甲、毛发、爪或蹄的特定部分的特性的化合物。本发明的化合物特别具有有利于透入指甲板的生理化学特性。