Substituted isoindoline-1,3 dione derivatives

• Main Author: JULIE FIELDS LIU
• Format: Patent
• Language: Chinese; English
• Published: 12.10.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel substituted isoindoline-1,3 dione derivatives and pharmaceutically acceptable salts thereof, in particular to novel substituted isoindoline-1,3 dione derivatives taken as apremilast analogues. The invention further provides composition containing the compounds and carriers, and an application of the compounds and the composition in methods for beneficially treating diseases and states through application of apremilast. 本发明涉及新的取代的异吲哚啉-1,3-二酮衍生物及其药学上可接受的盐。更具体地说，本发明涉及作为apremilast类似物的新的取代的异吲哚啉-1,3-二酮衍生物。本发明还提供包含本发明的化合物和载体的组合物，以及所公开的化合物和组合物在治疗通过施用apremilast有益地治疗的疾病和状态的方法中的用途。