Synthesis of vortioxetine via (2-(piperazine-1 -yl)phenvl)lithium intermediates

The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)lithium intermediates. 本发明提供用于生产1-(2-((2,4-二甲基苯基)硫基)苯基)哌...

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Bibliographic Details
Main Authors STERK DAMJAN, MARAS NENAD, ZUPANCIC BORUT
Format Patent
LanguageChinese
English
Published 14.09.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)lithium intermediates. 本发明提供用于生产1-(2-((2,4-二甲基苯基)硫基)苯基)哌嗪(沃替西汀,种用于治疗抑郁症和焦虑的药物)的新合成方法，该方法通过(2-(哌嗪-1-基)苯基)锂中间体来进行。
Bibliography:Application Number: CN2014874384