Synthesis method of linagliptin intermediate
The invention discloses a synthesis method of a linagliptin intermediate. The synthesis method comprises adding 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyne-1-yl)-8-bromoxanthine (e), (R)-3-Boc-aminopiperidine (f), potassium carbonate and acetonitrile into a reactor, carrying out uniform...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
31.08.2016
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a synthesis method of a linagliptin intermediate. The synthesis method comprises adding 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyne-1-yl)-8-bromoxanthine (e), (R)-3-Boc-aminopiperidine (f), potassium carbonate and acetonitrile into a reactor, carrying out uniform mixing and carrying out a reaction process under the conditions of heating reflux, a reaction temperature of 80-85 DEG C and reaction time of 24-48h, wherein a mole ratio of 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyne-1-yl)-8-bromoxanthine (e), (R)-3-Boc-aminopiperidine (f) to potassium carbonate is 1: (1.2-1.6): (3-7) and a ratio of 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyne-1-yl)-8-bromoxanthine (e) to acetonitrile is 100: (400-1000)g/ml. The synthesis method of the linagliptin intermediate (g) prevents generation of debromination impurities (i), is simple and easy in a post-treatment step and solves the problem that the intermediate is not easily separated from a solvent and is diffic |
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Bibliography: | Application Number: CN20161189177 |