天然产物Cocosolide及其结构类似物

• Format: Patent
• Language: Chinese
• Published: 20.07.2018
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; DERIVATIVES THEREOF; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

本发明涉及从关岛附近的浅石滩及Cocos环湖礁上的藻青菌种Symploco sp.中分离得到的含有木吡喃糖苷结构的二聚体大环内酯化合物Cocosolide及其结构类似物和它们的全合成方法，并验证了它们对于T细胞生长因子IL-2的优良抑制活性，具有很强的医药工业的应用前景。 The invention relates to a dimer macrolide compound Cocosolide, an analogue thereof and total synthesis methods of the Cocosolide and the analogue. The dimer macrolide compound Cocosolide containing a xylopyranoside structure is obtained through separation from cyanobacteria Symploco sp. on the reef flat and the Cocos lake-around reef near the Guam, excellent inhibition activity of the Cocosolide and the analogue for a T cell growth factor IL-2 is verified, and the Cocosolide and the analogue have very bright application prospect in the pharmaceutical industry.