Peptidomimetic compounds and antibody-drug conjugates thereof

• Main Authors: Carvalho Gustavo B D, Gunes Ibrahim S, Yalcin Baris, Williams Mark J
• Format: Patent
• Language: Chinese; English
• Published: 17.08.2016
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS

This invention relates to novel peptidomimetic compounds which are useful as linkers of antibody-drug conjugates (ADC). This invention also relates to ADCs containing peptidomimetic linkers and anthracycline derivatives. It is contemplated that the ADC of the present invention may be used to treat various diseases or disorders, e.g.characterised by the overexpression of a tumour antigen. 本发明公开了种组合物，该组合物包含：具有第重复单元的聚烯烃；中空玻璃微球；为化学上未交联的且不含极性官能团的聚烯烃抗冲改性剂；和包含第重复单元和第二重复单元的增容剂，该第二重复单元为利用极性官能团改性的第重复单元。还公开了由组合物制成的制品和通过注塑组合物来制备物品的方法。