Indazole compounds as 5-HT4 receptor agonists

• Main Authors: Jasti Venkateswarlu, Mohammed Abdul Rasheed, Gagginapally Shankar Reddy, Shinde Anil Karbhari, Nirogi Ramakrishna
• Format: Patent
• Language: Chinese; English
• Published: 17.08.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel indazole compounds of the Formula (I), wherein, R1 is alkyl or cycloalkyl; (Formula II) including their stereoisomers and their pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-Hydroxytryptamine 4 (5-HT4) receptor agonists 本发明涉及式(I)的新吲唑化合物，包括其立体异构体及其可药用盐，其中R是烷基或环烷基；(式II)本发明还涉及制备这样的化合物的方法和包含这样的化合物的药物组合物。本发明的化合物可用于治疗与5-羟基-色胺4(5-HT)受体激动剂相关的多种疾病。