Compounds and use for treating cancer

• Main Authors: KITAMBI SATISH, ERNFORS PATRIK, HAMMARSTROM LARS, FARNEGARDH KATARINA, GRAVENFORS YLVA
• Format: Patent
• Language: Chinese; English
• Published: 17.08.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to certain 2,4-disubstituted quinoline derivatives, to their therapy, as well as to pharmaceutical compositions comprising said compounds. More specifically the invention relates to certain 2,4-disubstituted quinoline derivatives or pharmaceutical compositions comprising said compounds for the treatment of cancers characterized by overactive Ras and/or Rac or signalling pathway. 本发明涉及某些2,4-二取代的喹啉衍生物、涉及其疗法、以及涉及包含所述化合物的药物组合物。更具体地，本发明涉及用于治疗特征为过度活性的Ras和/或Rac或信号通路的癌症的某些2,4-取代的喹啉衍生物或包含所述化合物的药物组合物。