Compounds for positron emission tomography
Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as fo...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
10.08.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.
在此描述了用于使用正电子发射断层术诊断和/或监测病原性疾病的化合物、组合物以及方法。还描述了具有化学式B-L-P的共轭物,其中B是选自维生素受体结合配体(诸如叶酸)、PSMA结合配体、或PSMA抑制剂的靶向剂的自由基;L是二价接头,该二价接头包含天冬氨酸、赖氨酸、或精氨酸,并且P是显像剂或放射治疗剂,诸如放射性核素或含放射性核素基团的自由基,或者是能够结合放射性核素诸如金属螯合基团的化合物的自由基。 |
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Bibliography: | Application Number: CN201480071256 |