Preparation and application of MIP (molecularly imprinted polymer) with tropane alkaloid drug specificity

• Main Authors: WANG SHANSHAN, JIN FEN, WANG JING, ZHENG LUFEI, SHE YONGXIN, ZENG SHAOMEI, JIN MAOJUN, SHAO HUA
• Format: Patent
• Language: Chinese; English
• Published: 27.07.2016
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING

The invention relates to the field of drug extraction, separation and purification, in particular to an MIP (molecularly imprinted polymer) with tropane alkaloid drug specificity. The MIP is mainly prepared from anisodine, methacrylic acid, trimethylolpropane trimethacrylate, 2,2'-azobis(2-methylpropionitrile) and a pore-foaming agent through a reaction, wherein the adding mole ratio of anisodine to methacrylic acid is 1:4-1:8, the adding mole ratio of trimethylolpropane trimethacrylate to methacrylic acid is 4:1-6:1, and the adding mole ratio of 2,2'-azobis(2-methylpropionitrile) to methacrylic acid is 15 mg:1 mmol-25 mg:1 mmol. Through selection of kinds and dosage of a solvent, a functional monomer, a crosslinking agent and an initiator and optimization of polymerization conditions, the MIP with better particle size distribution, physical stability and excellent adsorption is prepared, can selectively recognizing four tropane alkaloids and has good class specificity. 本发明涉及药物萃取及分离纯化领域，具体而言，涉及种托烷类生物碱药物特异性分子印