Inhibitors Of Protein Tyrosine Kinase Activity

• Main Authors: ISAKOVIC LJUBOMIR, GAUDETTE FREDERIC, VAISBURG ARKADII, CLARIDGE STEPHEN WILLIAM, ZHAN LIJIE, SAAVEDRA OSCAR MARIO, DEZIEL ROBERT, UNO TETSUYUK, MANNION MICHAEL, ZHOU NANCY Z, RAEPPEL STEPHANE, RAEPPEL FRANCK
• Format: Patent
• Language: Chinese; English
• Published: 20.07.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to compounds of Formula (I) and their use for inhibiting protein tyrosine kinase activity In Formula (I), the group M is thieno[3,2,b]pyridinyl as shown, and the group D is a ring or ring system, and the groups Z, Ar, and G are as defined herein The invention relates particularly to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling The invention also provides compositions and methods for treating cell proliferative diseases and conditions, such as cancer, and for treating ophthalmic diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR). 本发明涉及式(I)化合物及其抑制蛋白酪氨酸激酶活性的用途。在式(I)中，如所示基团M为噻吩并[3,2?b]吡啶基且基团D为环或环体系，且基团Z、Ar和G如本文定义。本发明尤其涉及下述化合物，其抑制生长因子受体的蛋白酪氨酸激酶活性，从而抑制受体信号传导，例如抑制VEGF受体信号传导和HGF受体信号传导。本发明还提供了组合物和治疗细胞增殖性疾病和病症如癌症的方法，和治疗眼病的方法，包括与年龄相关的黄斑变性(AMD)和糖尿病性视网膜病(DR)。