An amorphous and a crystalline form of Genz 112638 hemitartrat as inhibitor of glucosylceramide synthase

• Main Authors: COPELAND DIANE P, MARSHALL JOHN, BHARDWAJ RENU, SIEGEL CRAIG, CHENG SENG, WILLIS CHRIS, HARIANAWALA ABIZER, LIU HANLAN, SKELL JEFFREY, PALACE GERARD, KOCHLING JIANMEI, PETERSCHMITT JUDITH
• Format: Patent
• Language: Chinese; English
• Published: 20.07.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The hemitartrate salt of a compound represented by the following structural formula (as shown in the description): (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described. 公开了由以下结构式代表的化合物的半酒石酸盐：(式I半酒石酸盐)，其可用于药学应用。式(I)半酒石酸盐的特定单晶型的特征在于多种性质和物理测量。此外也公开了制备结晶的式(I)半酒石酸盐的方法、以及用它抑制受试者的葡糖神经酰胺合酶或降低受试者的鞘糖脂浓度，从而治疗多种疾病。也描述了药物组合物。