SALT AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE

The invention provides salt and solvates of a tetrahydroisoquinoline derivative. (S)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid in substantially pure form is described together with its sodium salt and solvates. Methods for preparing the compound...

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Bibliographic Details
Main Authors MCCARTHY THOMAS DAVID, BOYLE CRAIG JAMES STEWART, KELLY PETER MICHAEL, EBERLIN ALEXANDER REDVERS
Format Patent
LanguageChinese
English
Published 20.07.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides salt and solvates of a tetrahydroisoquinoline derivative. (S)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid in substantially pure form is described together with its sodium salt and solvates. Methods for preparing the compound, its sodium salt and its solvates and pharmaceutical compositions comprising them are also described. 本发明涉及四氢异喹啉衍生物的盐和溶剂合物，具体描述了基本纯化形式的(S)?2?(二苯基乙酰基)?1,2,3,4?四氢?6?甲氧基?5?(苯基甲氧基)?3?异喹啉羧酸与其钠盐和溶剂合物。也描述了制备所述化合物、其钠盐和其溶剂合物以及含有其的药物组合物的方法。
Bibliography:Application Number: CN201610152658