Anti-thrombus active peptide and preparation method thereof

A peptide which does not cause substantial thrombocytopenia at the minimum dose at which the peptide exhibits in vivo the activity of inhibiting the binding of von Willebrand factors with platelets is obtained by reacting an oligopeptide derived from a venom having the above activity with a protein...

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Bibliographic Details
Main Authors FUKUCHI NAOYUKI, NAGANO MITSUYO, YAMAMOTO HIROSHI
Format Patent
LanguageEnglish
Published 25.10.2000
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:A peptide which does not cause substantial thrombocytopenia at the minimum dose at which the peptide exhibits in vivo the activity of inhibiting the binding of von Willebrand factors with platelets is obtained by reacting an oligopeptide derived from a venom having the above activity with a protein modifier and glutathione and/or cysteine to thereby break the disulfide bonds between the peptide chains constituting the oligopeptide while substantially preserving the disulfide bonds within the peptide chains intact. The above peptide, its variant or a part thereof is produced by the genetic engineering technique using genes that code for the same.
Bibliography:Application Number: CN19941094226