Oil-based adjuvants

• Main Authors: LIGHTLE SANDRA ANN MARIE, MEDIRATTA SANGITA, KREBS RICHARD LEE, FOSS DENNIS L, FONTAINE MICHAEL CHRISTOPHER, HARDHAM JOHN MORGAN, DONACHIE WILLIAM, DOMINOWSKI PAUL JOSEPH, SMITH DAVID GEORGE EMSLIE, JAGLARZ ANITA DOROTA, MAHAN SUMAN, VORA SHAUNAK, MWANGI DUNCAN, RAI SHARATH K, WILMES LAUREN, SALMON SARAH A, FITZPATRICK JULIE LYDIA, MOHR KAORI, GALLO GUILLERMO
• Format: Patent
• Language: Chinese; English
• Published: 13.07.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals. 本发明提供了包含免疫刺激寡核苷酸、多聚阳离子载剂、固醇、皂苷、季胺、TLR?3激动剂、糖脂以及MPL?A或其类似物于油乳液中的组合的各种配方，其制备免疫原性组合物和疫苗的用途，以及其治疗动物的用途。