Antigen epitope minimum motif peptides of human papilloma virus (HPV) 18 carinogenic E6 and E7 proteins

• Main Authors: WANG JIAN, XUE FENG, XU WANXIANG, LIAN WENBO, WANG LI, LIU RITING, TANG HAIPING, XU CHEN, ZHAN JIANMIN
• Format: Patent
• Language: Chinese; English
• Published: 13.07.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The invention provides antigen epitope minimum motif peptides of human papilloma virus (HPV) 18 carinogenic E6 and E7 proteins. The antigen epitope minimum motif peptides can be specifically combined with an anti-HPV18 antibody, and single epitope peptide antigens are highly specific and can be combined, so the sensitivity and the specificity of detection are improved (the dilution degree of a serum sample is improved). 本发明提供了人乳头瘤病毒(HPV)18型致癌性E6和E7蛋白的抗原表位最小基序肽，其可特异性地与抗HPV18型抗体进行结合；并且由于单个表位肽抗原是高度特异性的，可以组合应用，因此可提高检测的灵敏度(提高检测血清样本的稀释度)和特异性。