Nanometer andrographolide suspension composition, and preparation method and application of composition

• Main Authors: GUO LIGANG, CHENG XIAOBO, KONG DEXIAN, LI ZHIGANG, DENG YIHUI, ZHANG TING, LUO XIANG, LI JING, ZHANG GANG, FAN DI, QUAN JINGJING
• Format: Patent
• Language: Chinese; English
• Published: 06.07.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of a medicinal preparation, and discloses a nanometer andrographolide suspension composition, and a preparation method and an application of the composition. A formula of the composition comprises, by mass percentage, 0.05-5% of andrographolide, 0.5-5% of a stabilizing agent, and 0.005-1% of a dilution stabilizing agent, with the balance being distilled water, and the formula is free of organic solvent. The nanometer andrographolide suspension is stable in quality, can be prepared into a nanometer preparation with a size of 100-1000 nm, and has characteristics of simple process, easy industrialization, large drug loading capacity, convenient drug administration, and high safety. A proper amount of a freeze-drying protective agent is added, and the composition can be freeze-dried for storage. Before use, the composition is directly dissolved and diluted with 5% of glucose, and is used for intravenous injection and intramuscular injection. Otherwise, an excipient is added into