New inhibitors of cyclophilins and uses thereof

• Main Authors: COLLIANDRE LIONEL, GUICHOU JEAN-FRANCOIS, PAWLOTSKY JEAN-MICHEL, AHMED-BELKACEM HAKIM
• Format: Patent
• Language: Chinese; English
• Published: 22.06.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a compound of formula (I): Formula (I), wherein: - n is 0, 1 or 2; - A is in particular CH or N; - X is in particular CO, SO2, CS, and R1 is in particular H, - R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, - R6 is in particular H or an alkyl group, and - R7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections. 本发明涉及式(I)的化合物，其用于预防和/或治疗病毒性疾病或感染，式(I)中：-n为0、1或2；-A特别为CH或N；-X特别为CO、SO、CS，并且R特别为H，-R是式NRR或OR的基团，R和R特别为H，并且R为烷基，-R特别为H或烷基，并且R特别为芳基，且其被至少个NH基取代。