INCLUSION COMPLEXES OF N-ETHOXYCARBONYL-3-MORPHOLINO-SYDNONIMINE OR SALTS FORMED WITH CYCLODEXTRINE-DERIVATIVES

Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pector...

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Bibliographic Details
Main Authors JOZSEF GAAL, JOZSEF SZEJTLI, MARIA VIKMON NEE KIRALY
Format Patent
LanguageEnglish
Published 04.12.1991
Edition5
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pectoris. It also has antiarrhythmic, fibrinolytic, platelet aggregation inhibitory and hypotensive activity. Pref. (III) are selected from beta-cyclodextrin (BCD), gamma-cyclodextrin, heptakis-2,6,O-dimethyl -beta-cyclodextrin and hydroxypropyl- beta-cyclodextrin.
Bibliography:Application Number: CN19911002687