Sulfamate serving as indoleamine-2, 3-dioxygenase inhibitor and preparation method and application thereof

• Main Authors: WANG ZHAOYIN, ZHU JIDONG
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides sulfamate serving as an indoleamine-2, 3-dioxygenase inhibitor and a preparation method and application thereof. The structure of the inhibitor is shown in the general formula I, wherein definitions of X, R1, R2, R3, R4, R5 and n are shown in the description and the claim. The invention further discloses the preparation method of the inhibitor. The compound shown in the general formula I can serve as the indoleamine-2, 3-dioxygenase inhibitor and is used for preparing medicine for preventing and/or treating indoleamine-2, 3-dioxygenase mediated diseases. The general formula I is shown in the description. 本发明提供了种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途。本发明的抑制剂，结构如通式I所示，其中，X、R、R、R、R、R、n的定义如说明书和权利要求书中所示。本发明还公开了抑制剂的制备方法。本发明的通式I化合物，可以作为吲哚胺-2,3-双加氧酶抑制剂，用于制备预防和/或治疗吲哚胺-2,3-双加氧酶介导的疾病的药物。