Substituted azole penta-heterocyclic derivatives and solvothermal one-pot synthesis method and application thereof

• Main Authors: CHEN LIANQING, WAN ZILU, NIU XIONGLEI
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2016
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; POLISHES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of organic synthesis and particularly discloses a series of substituted azole penta-heterocyclic derivatives and a solvothermal one-pot synthesis method thereof. By the adoption of the solvothermal one-pot synthesis method for preparing the target product, reaction time is short, a solvent is not prone to volatilization in an airtight system, recycling can be realized, production cost is effectively reduced, the advantages of energy conservation and environment friendliness are achieved, operation is easy, yield is high, and the prepared substituted azole penta-heterocyclic derivatives have good anti-microbial biological activity and excellent photophysical properties such as electron conductivity, the fluorescence property and the ultraviolet property, thereby having very high development and application value. 本发明属于有机合成技术领域，具体公开了系列取代唑类五元杂环衍生物及其溶剂热锅合成方法。本发明采用溶剂热锅合成法制备目标物，反应时间短，溶剂在密闭体系内不易挥发，可回收利用，有效降低了生产成本，具有节能环保的优点，并且操作简单，收率较高，制备得到的取代唑类五元杂环衍生物具有很好的抗菌生物活性，而且具有优良的电子