Synthesis method for montelukast

The invention discloses a synthesis method for montelukast. 1-(mercaptomethyl)- cyclopropaneacetic acid and alkali are added into organic solvent, and the mixture is subjected to a stirred reaction at 10 DEG C-30 DEG C to obtain a dianion alkaline solution; a quinolinediol compound and triethylamine...

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Main Authors ZHANG ZHAOZHEN, YANG QINGKUN, JIANG HAIPING, WU KE, ZHOU XUEWEN, ZHOU XIANGUO, GAO DALONG, YANG BOYONG, DONG TINGHUA
Format Patent
LanguageChinese
English
Published 04.05.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a synthesis method for montelukast. 1-(mercaptomethyl)- cyclopropaneacetic acid and alkali are added into organic solvent, and the mixture is subjected to a stirred reaction at 10 DEG C-30 DEG C to obtain a dianion alkaline solution; a quinolinediol compound and triethylamine are dissolved into organic solvent to obtain a quinolinediol solution; paratoluensulfonyl chloride is dissolved into organic solvent to obtain a paratoluensulfonyl chloride solution; then flow speed is controlled to inject the quinolinediol solution and the paratoluensulfonyl chloride into a micro-reactor for a mixed reaction at 10 DEG C-30 DEG C to obtain a tosylate compound solution; then the tosylate compound solution and the injected 1-(mercaptomethyl)-cyclopropaneacetic acid dianion alkaline solution are subjected to a mixed reaction at 10 DEG C-30 DEG C to obtain montelukast feed liquid which is discharged out of the micro-reactor, and the montelukast solid is obtained through post-treatment. The synthesis m
Bibliography:Application Number: CN2016196340