Fluorescence-SERS dual-mode super-resolution imaging probe and its preparation method and use method

The invention discloses a fluorescence-SERS dual-mode super-resolution imaging probe and its preparation method and use method. The fluorescence-SERS dual-mode super-resolution imaging probe is characterized in that 1, silica is coated with metal yolk-eggshell structure composite nanoparticles so th...

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Bibliographic Details
Main Authors LU JU, CUI YIPING, ZONG SHENFEI, WANG ZHUYUAN, CHEN CHEN
Format Patent
LanguageChinese
English
Published 13.04.2016
Subjects
ADHESIVES
CHEMISTRY
DYES
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE
MEASURING
METALLURGY
MISCELLANEOUS APPLICATIONS OF MATERIALS
MISCELLANEOUS COMPOSITIONS
NATURAL RESINS
PAINTS
PHYSICS
POLISHES
TESTING
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Summary:The invention discloses a fluorescence-SERS dual-mode super-resolution imaging probe and its preparation method and use method. The fluorescence-SERS dual-mode super-resolution imaging probe is characterized in that 1, silica is coated with metal yolk-eggshell structure composite nanoparticles so that the probe is prepared, 2, a Raman molecule with a fluorescence signal is added into the cavity of the probe so that fluorescence-SERS signal switching is realized, and 3, the shell surface of the silica is labeled through a specific targeting ligand for specific organelle super-resolution optical imaging. The fluorescence-SERS dual-mode super-resolution imaging probe realizes fluorescence-SERS dual-mode super-resolution optical imaging.
Bibliography:Application Number: CN201510836925