Solid forms of Valsartan-Sacubitril trisodium compound, and preparation method and use thereof

The invention relates to a crystal form A and amorphous alpha, beta and gamma of a Valsartan-Sacubitril trisodium compound, and a preparation method thereof. The crystal form A and the amorphous alpha, beta and gamma have the advantages of simple preparation method, good stability and solubility, an...

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Main Authors HE YONGYAO, ZENG QIN, ZHAO YONGLONG, HUANG ZHILONG, LUO JIE, HUI SHUAI, XIANG ZHIXIANG, QIAN CHUNXIA, CHEN DAFENG, LI FANGQUN
Format Patent
LanguageChinese
English
Published 06.04.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a crystal form A and amorphous alpha, beta and gamma of a Valsartan-Sacubitril trisodium compound, and a preparation method thereof. The crystal form A and the amorphous alpha, beta and gamma have the advantages of simple preparation method, good stability and solubility, and suitableness for preparing various preparations. The invention also relates to a medicinal composition containing the crystal form or the amorphous substances, and a use of the compound in the preparation of drugs for preventing or treating chronic heart failure or hypertension.
Bibliography:Application Number: CN201510618916