Nano particle composition and anti-tumor application thereof

• Main Authors: ZHENG JUNNIAN, KONG XIANGFU, SHEN ZAN, LIN-LI JIAMI, YAO HONG
• Format: Patent
• Language: Chinese; English
• Published: 23.03.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a nano particle composition and anti-tumor application thereof. The nano particle composition is a nano particle formed by assembling a polymer carrier and plasmid for expressing a therapeutic gene; the polymer carrier is a cyclodextrin-polyethyleneimine-polyethylene glycol-folic acid quaternary assembly-type polycation carrier, and the plasmid for expressing the therapeutic gene is eukaryotic expression plasmid containing an HGFK1 protein DNA sequence for coding a hepatocyte growth factor. Compared with the prior art, the nano particle has the advantages of being efficient and tumor targeted; the nano particle can be automatically assembled in an aqueous solution through electrostatic interaction, and the particle size of the nano particle and the stability in a salt solution has an important effect on the function of the nano particle; it is verified that the nano particle composition can prevent transfer or relapse of a cancer and alleviate or relieve or control or improve or cure