特发性脊柱侧凸的严重进展的新标记物及其用于分层脊柱侧凸患者和预测发展脊柱侧凸的风险的用途

• Format: Patent
• Language: Chinese
• Published: 21.05.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

提供将患有青少年特发性脊柱侧凸(AIS)或处于发展青少年特发性脊柱侧凸(AIS)的风险的受试者分层为诊断上或临床上有用的亚类的方法。所述分层是基于所述受试者的PTPμ表达和/或活性和/或PIPK1γ表达和/或活性。还提供也基于所述受试者的PTPμ表达和/或活性和/或PIPK1γ表达和/或活性预测发展脊柱侧凸的风险的方法；以及增加有需要的受试者的细胞中的GiPCR信号传导的方法，所述方法包括向所述受试者的细胞施用有效量的PIPK1γ酪氨酸磷酸化的抑制剂；PIPK1Y酪氨酸去磷酸化的活化剂；和/或PIPK1γ表达和/或活性的抑制剂。 Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expressio