Long-acting leuprorelin acetate microsphere and preparation method thereof

The invention relates to a chemical drug microsphere preparation and a preparation method thereof, in particular to long-acting leuprorelin acetate microsphere and a preparation method thereof. The raw materials of the leuprorelin acetate microsphere include leuprorelin acetate, a glycolide lactide...

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Bibliographic Details
Main Authors PANG GUICAI, CEN ZHENNING, GUO GUANGMING, HUANG SIHUAN
Format Patent
LanguageEnglish
Published 03.02.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a chemical drug microsphere preparation and a preparation method thereof, in particular to long-acting leuprorelin acetate microsphere and a preparation method thereof. The raw materials of the leuprorelin acetate microsphere include leuprorelin acetate, a glycolide lactide copolymer, mannitol and gelatin. The microsphere and the preparation process provided by the invention select appropriate PLGA and unique production process parameters, thus developing the leuprorelin acetate microsphere with release time up to 3 months. And the release rate and yield of the microsphere provided by the invention are superior to the prior art.
Bibliography:Application Number: CN20151813372