Synthesis method of antibacterial agent cefoxitin acid

• Main Authors: ZHU CHANGFAN, LIANG JIANZHONG, LU ZUQIANG
• Format: Patent
• Language: English
• Published: 06.01.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthesis method of an antibacterial agent cefoxitin acid. The method comprises the following steps: with 7-aminocephalosporanic acid as a raw material, dissolving the aminocephalosporanic acid with a weak alkaline solution; adding an etherified enzyme to the weak alkaline solution, adding a methoxide reagent, carrying out etherification reaction, and filtering out the etherified enzyme after etherification reaction is ended; adding solidified enzyme to a feed liquid for carrying out hydrolysis; after hydrolysis is ended, adding ethyl acetate to the solution, and beginning to drop a 2-thiophene acetyl reagent; after reaction is ended, dropping a benzthine cellulose acetate water solution to a reaction liquid, and separating out crystal to obtain a compound I; and reacting the compound I with an ammonia methoxyl acylation reagent, and introducing carbamyl methoxyl group to the third site of the compound I to obtain the cefoxitin acid. The synthesis method is mild in reaction condition, simple in synthesis process and easy to implement; the yield is effectively improved; the production steps are shortened; the production cost is reduced; the product purity is improved; the energy consumption is reduced; the wastewater output is reduced; the synthesis method is suitable for carrying out large-scale production.