Preparation method of (R)-tetrahydrofuran-3-amine

The invention provides a preparation method of (R)-tetrahydrofuran-3-amine. The target product is obtained by conducting two steps of reactions including amidation and Hofmann degradation with (R)-tetrahydrofuran-3-formic acid as main materials. By means of the method, production and operation are e...

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Bibliographic Details
Main Authors MA JULIANG, LIU HUAIZHEN, GUO MING, SHEN NAITAO, MENG QINGLIANG, WANG JINGCHENG
Format Patent
LanguageEnglish
Published 06.01.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a preparation method of (R)-tetrahydrofuran-3-amine. The target product is obtained by conducting two steps of reactions including amidation and Hofmann degradation with (R)-tetrahydrofuran-3-formic acid as main materials. By means of the method, production and operation are easy, the production cycle is short, the product yield is high, no racemate is generated in the production process, the product quality is stable, cost is low, and the method is suitable for industrialized production.
Bibliography:Application Number: CN201510759051