Marker, application and detection method thereof and kit

The invention relates to the biotechnology field and in particular relates to a marker, an application and detection method thereof and a kit. The marker is post-translational modified fibrinogen (PTM-F). The detected PTM-F is an autoantigen related to the rheumatoid arthritis (RA) pathology. Abnorm...

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Bibliographic Details
Main Author LOU JIANRONG
Format Patent
LanguageEnglish
Published 16.12.2015
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The invention relates to the biotechnology field and in particular relates to a marker, an application and detection method thereof and a kit. The marker is post-translational modified fibrinogen (PTM-F). The detected PTM-F is an autoantigen related to the rheumatoid arthritis (RA) pathology. Abnormal post-translational modification of fibrinogen can happen at the early stage of RA, so that the PTM-F is detected at the early stage of RA. Besides, the phenomenon of inconformity, caused by difference of autoimmune systems, of the diagnosis results and the state of RA is excluded. The detected PTM-F has high specificity (above 90%) and sensitivity (above 80%) in the serums of RA patients, can reflect the pathological information of the patients and has high RA diagnostic significance. The detected PTM-F has clear target. The non-specific signals can be reduced to a great extent by capturing the target protein by using a specific monoclonal antibody during detection, thus avoiding background signal interference and false positive phenomena.
Bibliography:Application Number: CN20151591146