Azaquinazoline inhibitors of atypical protein kinase C

The present invention provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

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Bibliographic Details
Main Authors TAO MING, OLOWOYE IKEOLUWA, DUGAN BENJAMIN J, MESAROS EUGEN F, OTT GREGORY R, ZULLI ALLISON L, DORSEY BRUCE D, MORRIS EMMA L, ROFFEY JONATHAN R A, FOWLER KATHERINE M, MONCK NATHANIEL JT, SOUDY CHRISTELLE N, ZIFICSAK CRAIG A, BRESLIN HENRY J, PAVE GREGOIRE A, HUDKINS ROBERT L
Format Patent
LanguageEnglish
Published 25.11.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.
Bibliography:Application Number: CN201380062263