Transporter with glucose sensor for determining viability of organ or tissue

An apparatus for perfusing an organ or tissue includes a perfusion circuit and a glucose sensor operatively connected to the perfusion circuit. The glucose sensor is configured to detect a target agent that is an indicator of viability of the organ or tissue. The target agent may be Kidney Injury Mo...

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Bibliographic Details
Main Authors MAYER STEVEN L, MAYER TRACY H, KRAVITZ DAVID C
Format Patent
LanguageEnglish
Published 11.11.2015
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:An apparatus for perfusing an organ or tissue includes a perfusion circuit and a glucose sensor operatively connected to the perfusion circuit. The glucose sensor is configured to detect a target agent that is an indicator of viability of the organ or tissue. The target agent may be Kidney Injury Molecule-1 (KIM-1). The sensor includes a solid support, such as a bead or membrane, to which is attached a recognition molecule that specifically binds to the target agent but not significantly to other agents. The sensor also includes an enzyme that can catalyze the conversion of a substance to glucose. In the presence of the target agent the enzyme can convert the substance into glucose, which can then be detected and optionally be quantified by the sensor.
Bibliography:Application Number: CN201480016000