Podophyllotoxin phospholipid compound as well as pharmaceutical composition and application of podophyllotoxin phospholipid compound

• Main Authors: LING LONGBING, LI XINSONG, HE RUIYU, FANG SHUO
• Format: Patent
• Language: English
• Published: 11.11.2015
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a podophyllotoxin phospholipid compound as well as a pharmaceutical composition and application of the podophyllotoxin phospholipid compound. The pharmaceutical composition comprises a podophyllotoxin phospholipid compound or a combined pharmaceutical composition of the podophyllotoxin phospholipid compound and a pharmacologically-acceptable carrier and is a liquid preparation, a solid preparation, a semi-solid preparation, a capsule, granules, gel and an injection. The pharmaceutical composition is a liposome nanoparticle (with the particle size of 10-1000nm) prepared from the podophyllotoxin phospholipid compound or the podophyllotoxin phospholipid compound and an adjuvant. The podophyllotoxin phospholipid compound and the liposome nanoparticle thereof can be used as liquid preparations, solid preparations, semi-solid preparations, disinfection preparations and sterile preparations, are low in toxicity and can be used for efficiently treating tumors.