Synthesis method for near-infrared fluorescent probe copper nano-cluster and application of synthesis method

• Main Authors: ZHANG FEI, LI XINGE, LI YAN
• Format: Patent
• Language: English
• Published: 14.10.2015
• Subjects: ADHESIVES; CASTING; CHEMISTRY; DYES; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MAKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NANOTECHNOLOGY; NATURAL RESINS; PAINTS; PERFORMING OPERATIONS; PHYSICS; POLISHES; POWDER METALLURGY; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TESTING; TRANSPORTING; WORKING METALLIC POWDER

The invention discloses a synthesis method for a near-infrared fluorescent probe copper nano-cluster and a detection method for glycoprotein. The near-infrared fluorescent probe copper nano-cluster is synthesized through a one-pot method, aminophenylboronic acid is used for functionally transforming the synthesized copper nano-cluster, and the functionalized copper nano-cluster is obtained. Due to the specific action of boric acid groups on aminophenylboronic acid and cis diol in glycoprotein, the fluorescence intensity of the copper nano-cluster is quenched. A fluorescent probe can detect glycoprotein at high specificity and sensitivity. Glycoprotein widely exists in mucus, plasma, cytoplasm and cell membranes, is tightly related to living organisms, is an important physiological active material, and is tightly related to certain genetic diseases, and therefore important practical significance is provided for detecting glycoprotein.