肿瘤干细胞分子标记

• Format: Patent
• Language: Chinese
• Published: 13.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

本发明涉及分子标记，该分子标记为用于检测作为检测对象的细胞团中的肿瘤干细胞的分子标记，其在该检测对象所含的肿瘤干细胞中能检测到，但在非肿瘤干细胞的癌细胞和正常细胞中检测不到；还涉及以该分子标记为指标来判定判定对象中是否存在肿瘤干细胞的方法。进而，本发明涉及试剂盒，其为用于判定肿瘤干细胞是否存在的试剂盒，至少含有用于检测前述分子标记的试剂。进而，本发明还涉及前述分子标记所编码的多肽、识别该分子标记的基因表达产物的表位的抗体、抑制该分子标记表达的核酸、含有来源于该分子标记的基因的核酸疫苗。 A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhi