Method for producing (1S,4S,5S)-4-bromo-6- oxabicyclo[3.2.1]octane-7-one

The present invention addresses the problem of providing a method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octane- 7-one (1), which is important as an intermediate compound for the production of a FXa-inhibiting compound, with high efficiency. A method for producing (1S,4S,5S)- 4-bromo-6-...

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Bibliographic Details
Main Authors TAKAYANAGI YOSHIHIRO, NAKAMURA YOSHITAKA, FURUYA YUKITO
Format Patent
LanguageEnglish
Published 23.09.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention addresses the problem of providing a method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octane- 7-one (1), which is important as an intermediate compound for the production of a FXa-inhibiting compound, with high efficiency. A method for producing (1S,4S,5S)- 4-bromo-6-oxabicyclo[3.2.1]octane-7-one (1), said method being characterized by treating a (R)-[alpha]-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo- 5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.
Bibliography:Application Number: CN201480006378