Method for synthesizing benzil derivative

The invention discloses a method for synthesizing a benzil derivative. The method comprises the following steps: adding epoxy chalcone compound shown in the formula I, a Selectfluor oxidizing agent and inorganic base into a mixed solvent of acetonitrile and water, stirring for reaction for 4-8 h at...

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Bibliographic Details
Main Authors WANG HENG, ZHANG JIAN, LIU YUNKUI
Format Patent
LanguageEnglish
Published 23.09.2015
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for synthesizing a benzil derivative. The method comprises the following steps: adding epoxy chalcone compound shown in the formula I, a Selectfluor oxidizing agent and inorganic base into a mixed solvent of acetonitrile and water, stirring for reaction for 4-8 h at 60-100 DEG C, and treating a reaction liquid obtained after the reaction is finished to prepare the benzil derivative shown in the formula II. The synthesis method has the advantages that the raw materials are cheap and easy to obtain, transition metal catalysis is not needed, the oxygen source is easy to obtain and environment-friendly, the reaction condition is mild, the target substrate can be synthesized efficiently, the universality of the functional group is good, and the operation is simple and convenient.
Bibliography:Application Number: CN20151297776