Preparation method of new crystal form of dexrabeprazole sodium

The invention relates to a novel crystal form of a novel proton pump inhibitor R-Na-2-[[[4-(3-methoxypropoxy)-3-methylpyridyl]-2-yl]methylsulfinyl]-1H-benzimidazole (with the common name of dexrabeprazole sodium), and a preparation method thereof. A result of X diffraction determination of the above...

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Bibliographic Details
Main Authors WANG WEI, QIN YINLIN
Format Patent
LanguageEnglish
Published 16.09.2015
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a novel crystal form of a novel proton pump inhibitor R-Na-2-[[[4-(3-methoxypropoxy)-3-methylpyridyl]-2-yl]methylsulfinyl]-1H-benzimidazole (with the common name of dexrabeprazole sodium), and a preparation method thereof. A result of X diffraction determination of the above crystal compound shows that the X-ray powder diffraction pattern represented by (2theta +/-0.2)DEG has no characteristic diffraction peaks, and the compound is an amorphous crystal form. The preparation method concretely comprises the following steps: dissolving dexrabeprazole sodium in alkaline water, filtering, cooling for precipitating, carrying out pumping filtration, and carrying out vacuum drying.
Bibliography:Application Number: CN2014187571